Fatty Liver Disease

 

Fatty Liver Disease

Fat in the liver typically develops when a person consumes more fat and sugars than his or her body can handle. This is more common in people who are overweight or obese but can also occur in adults with healthy body weights. If fat builds up to more than 5% of the liver, then the liver is considered to be a fatty liver. Although having this condition may not cause any immediate harm, there is a concern that extra fat in the liver might make the liver vulnerable to further injury such as inflammation and scarring.

NAFLD

NAFLD

NASH

NASH

NAFLD in children

NAFLD in Children

Prevention and management

Prevention and management

Resource

NAFLD and NASH Resource Library

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What is Non-Alcoholic Fatty Liver Disease (NAFLD)?

Non-alcoholic fatty liver disease (NAFLD) is a liver disease affecting people who drink little to no alcohol. As the name implies, the main characteristics of NAFLD is too much fat stored in liver cells. NAFLD is the most common liver disease in Canada affecting about 20% of Canadians.

It tends to develop in people who are overweight or obese, particularly if they have lot of fat around the middle of their body (waist). It can also develop in a person whose body weight is in the healthy weight range, but who typically eats a lot of sugary and fatty foods and who has extra fat around the waist. NAFLD has shown to be strongly associated with metabolic syndrome—a health disorder characterized by a group of risk factors (large waist circumference, high blood pressure, high blood sugar levels, high cholesterol, and abnormal amounts of lipids in the blood) that greatly increase the risk of many chronic illnesses.

Causes

The most common cause of fatty liver disease in Canada is obesity. In 2018, almost 30% of Canadians 18 and older (roughly 7.3 million adults) reported height and weight that classified them as either overweight or obese.

Besides obesity, nutritional causes of fatty liver disease are:

  • Starvation and protein malnutrition
  • Long-term use of total parenteral nutrition (a feeding procedure that involves infusing nutrients directly into the bloodstream)
  • Intestinal bypass surgery for obesity
  • Rapid weight loss

Certain conditions often accompany and may contribute to fatty liver disease:

  • Diabetes mellitus
  • Hyperlipidemia (elevated lipids in the blood)
  • Insulin resistance and high blood pressure

Other causes include:

  • Genetic factors
  • Drugs and chemicals

How do we define “Overweight” and “Obese”?

A body mass index chart showing the risk for fatty liver diseaseAlthough many people feel they could lose some weight, few would consider themselves obese. A widely-used measure to define “overweight” and “obese” is the Body Mass Index (BMI). A BMI is a calculation based on your height and weight that gives a number that reflects either a healthy or unhealthy weight.

You can use the following formula to calculate your BMI: 

BMI:
Weight in kg
________________
(Height in meters)2

Example: For someone who is 1.70 meters tall who weighs 80 kilograms…

BMI  = 80 ÷  (1.70 x 1.70) = 27.7

Click here to access the BMI Calculator

UnderweightNormalOverweightObese
Less than 18.519.6-24.925-29.930 or greater

Note: Different ethnic groups may differ slightly. For example, in Asian populations the healthy BMI is lower, ranging from 18 – 23.

A green apple is wrapped up in a measuring tape commonly used to measure one's bodyDoes the size of your waist matter?

Excess abdominal fat is associated with fatty liver disease and other health risks such as diabetes. Waist measurements−which differ according to gender—are used to identify the health risks associated with excess abdominal fat.

  • For men, health risks increase if your waist circumference is more than 102 cm (40 in.)
  • For women, health risks increase if your waist circumference is more than 88 cm (35 in.)

It is important to measure your waist circumference in a consistent way. The best way to do this is:

  • Wrap a measuring tape around yourself at a level 2 cm higher than your belly button.
  • The tape should be snug but not pressing into your bare skin.
  • Relax, exhale, and read the measurement.

How does fat get into the liver?

Fat and sugars from a person’s diet are usually broken down by the liver and other tissues. If the amount of fat or simple sugar intake exceeds what is required by the body, fat is stored in the fatty tissue. Other reasons for the accumulation of fat in the liver could be the transfer of fat from other parts of the body or the inability of the liver to change it into a form that can be eliminated.

Symptoms

In general, people with fatty liver disease have no symptoms. However, some people report discomfort in the abdomen at the level of the liver, fatigue, a general feeling of being unwell, and vague discomfort.

Diagnosis

Fatty liver disease is usually suspected in people who are overweight and obese (particularly those with large waist circumferences), who have evidence of dyslipidemia (high cholesterol and lipids in the blood), insulin resistance and/or abnormal liver tests.

An ultrasound or Fibroscan® of the liver can show the presence of a fatty liver. In some cases, your doctor may advise a liver biopsy, a procedure where the physician inserts a needle into the liver and extracts sample tissue, which is then examined under a microscope.

What is NASH?

Normal, healthy liver compared to a liver with NASH

NASH stands for non-alcoholic steatohepatitis and is the more serious form of NAFLD. NASH affects almost 1.5 million Canadians, even those who drink little or no alcohol. Not only can NASH cause liver scarring, called fibrosis, but about 1 out of 5 adults with NASH can develop potential damage to liver function called cirrhosis.

NASH patients are also at greater risk of liver cancer, and for about 1 out of 10 people with NASH, it may lead to liver failure and the need for a liver transplant.

What’s the difference between NASH and NAFLD?

While a simple fatty liver is a rather benign condition, NASH is often associated with ongoing liver damage and can lead to cirrhosis of the liver, liver cancer, and the need for a liver transplant.

Symptoms

As with NAFLD, people with NASH generally have limited symptoms. Although rare, some children may present with vomiting and tenderness of an enlarged liver.

What could happen to people with NASH?

Currently, the long-term outlook of people with NASH is not well understood. In most cases, NASH seems to be a slowly progressive disease. However, there is a small proportion of NASH patients whose cirrhosis will become more severe, possibly leading to liver cancer or liver failure. In chronic liver failure, a liver transplant may be needed.

Treatment of NAFLD and NASH

When there is a buildup of simple fat, the liver becomes vulnerable to further injury, which may result in liver inflammation and scarring. The treatment of fatty liver disease is related to the cause. At this time, it is not possible to predict which patients will develop NASH.

Optimal treatment for NAFLD and NASH has not yet been established. People are advised to address their risk factors (i.e., to improve their blood sugar control/monitoring if they are diabetic and to achieve gradual and sustained weight loss).

It is usually recommended that those diagnosed with NASH should avoid drinking alcohol. Lifestyle modification and excellent control of other illnesses are important for all patients with NAFLD and NASH.

Currently, there is no proven treatment with medication for NAFLD and NASH. Since it is now such a common health condition, NASH has raised much interest in the scientific community. There are numerous clinical trials for various treatments of NASH and several promising drug therapies that are anticipated to pave the way for new and more effective treatment options.

Can children develop fatty liver disease?

Fatty liver disease is now becoming evident in children, due in large part to an alarming increase in childhood obesity. Currently:

  • It is estimated that one Canadian child in 10 is overweight, a number that has almost tripled in the last decade.
  • In Canada, fatty liver disease is thought to occur in one in five overweight or obese children.
  • Fatty liver disease affects almost 3% of children and 25–55% of obese children.
  • Fatty liver disease can be found in children as young as two years of age.
  • Fatty liver disease can also occur in children with healthy body weights but who may have larger waist circumferences than other children of the same weight and height.
  • Fatty liver disease is more common in boys than girls and tends to occur in children of Caucasian or South Asian ancestry.
  • Fatty liver disease is more common in children who have family members with fatty livers or type 2 diabetes.
  • The cause of fatty liver disease is understood to be related to factors such as diets high in fatty foods and simple sugars and inactive lifestyles, particularly in children or adolescents who are overweight or obese.

In childhood, a fatty liver can be caused by a variety of disorders including those related to problems with copper metabolism (e.g., Wilson Disease), viral hepatitis, or a variety of autoimmune diseases.  It is very important that your doctor makes sure that your child does not have these conditions first.

NAFLD can only be diagnosed in children after all other potential causes of fatty liver have been ruled out.  If your doctor or healthcare provider thinks your child may be at risk for NAFLD, they may order some blood tests and an ultrasound of the abdomen to determine whether your child has NAFLD or not.  Consult your doctor about what types of tests your child needs to undergo to determine if your child has NAFLD.

When it comes to children, measuring waist circumference and your child’s height can help you determine if your child is depositing extra fat around the middle of their body. It is important to measure your child’s waist circumference, in the same way, each time it is done.

The exact number that you get for a child’s waist circumference is not what is important, as each child grows at different rates and so each child may have a different number.  A general rule of thumb is to measure the ratio between your child’s waist circumference and their height (in centimetres).  A ratio greater than 0.5 may mean that the child is depositing a little extra fat around their middle. However, it does NOT mean your child has NAFLD.

Waist-to-height ratio =     WC (cm)

                                      Height (cm)

Healthy Body Weights for Children

The best tool to decide if your child’s body weight is in the healthy range is to plot your child’s weight and body mass index (BMI) on growth curves.  A healthy body weight is when your child’s weight or BMI falls between the third percentile and the 95th percentile. If your child’s BMI is above the 95th percentile then your child is obese.  If your child’s BMI is between the 85th percentile and 95th percentile, they may be overweight.

It is important to follow the ‘trend’ of where your child is ‘tracking’ on the growth curve and not just one point in time. Remember your child is growing and so you should expect that your child’s BMI will change with time.

BMI is calculated exactly like adults. Your child’s weight (in kg) divided by your child’s height (in meters) squared.

Fatty Liver Disease: Prevention and Management

By adopting a healthy lifestyle, you may prevent obesity – the number one reason for fatty liver disease. It is important to remember that a healthy diet and exercise are important components of any weight-loss regimen.

Incorporating these easy everyday tips on nutrition, daily activity, exercise and sleep can help decrease your risk of NAFLD and NASH and increase your chances of feeling more energized and less stressed.

Nutrition

Nutrition

Activity

Physical Activity

Sleep

Sleep

Nutrition

A change in diet plays a significant part in how NAFLD may be treated and certainly how it can be prevented. Consuming too much sugar and saturated fat in your diet can have a similar effect as too much alcohol—fat build-up in the liver. Although there is no specific ‘liver healthy diet,’ these general guidelines of what and how much to eat can help ensure that your liver is functioning at its best!

Added Sugar

The World Health Organization (WHO) guideline recommends adults and children reduce their daily intake of added sugars to less than 10% of their total energy intake. That’s less than 50 grams of added sugars per day!* Learn more (English or French).


5 ways to reduce added sugarSample menus demonstrating how to reduce added sugar

Examples on how to choose healthier food options

  • Eat small regular meals. Do not skip meals or over-eat.
  • Drink 6 to 8 glasses of fluids (preferably water) a day.
  • Regularly choose a variety of whole foods including fruits and vegetables, protein sources (legumes, lean meats), whole grains (quinoa, wild rice), dairy (low-fat yogurt, milk and cheese) and sources of healthy fat (nuts, avocado, fatty fish).
  • Increase your intake of fresh fruits and vegetables, especially brightly coloured ones with deep bright pigments such as oranges, yellows, reds and greens. Fruits and vegetables are high in antioxidants, which are vital for overall liver health.
  • Maximize consumption of raw vegetables with high sulphur content (i.e. broccoli, Brussels sprouts, cabbage, cauliflower, garlic and onions).
  • Wash fruit and vegetables right before use to remove pesticides. Avoid washing too far ahead to reduce sweating or spoilage.
  • When cooking vegetables and fruits, steam or bake them. This retains more nutrients than boiling.
  • Moderate your consumption of saturated fat and simple sugar, as high intakes of sugar (fructose) sweetened beverages and fatty foods high in saturated fat have been associated with an increased risk for developing a fatty liver.
  • Drink black coffee (two to three cups a day). Studies have shown this may help improve or protect the liver from some diseases.
  • Consume vitamin D fortified dairy products, and vitamin D fortified plant-based foods to ensure your vitamin D needs are met. This is important to promote liver health and a healthy body weight.
  • Choose whole-grain products over white/bleached/refined products.

Physical Activity

Recognizing the difference between physical activity and exercise is the first step to living a lifestyle filled with more movement! While exercise is something best done with a moderate to high intensity and a structured routine, the goal of physical activity is do anything you can that gets you moving and can be physically demanding. It is important to decrease your sedentary activity time. Here are some tips to decrease your time spent in sedentary activity and become more active!

  • Consider completing chores or running errands like cleaning, shopping, mowing the law/gardening or shoveling snow.
  • Use ‘active transportation’ to get where you need to go, whether that includes walking, biking or running instead of driving.
  • Limit the screen time of you and your loved one as much as possible (experts suggest two hours a day for children)
  • Set an example with your family. If you have kids, walking to or from school or the store.
  • Park a little further away when going shopping.
  • If you work a desk-job, take small and frequent breaks to stretch.
  • Consider also creating opportunities to walk during your lunch break, or before/after work.
  • Encourage your family to take part in a physical activity together, like bike riding, hikes or walks around the neighbourhood.
  • Get off the bus one stop early
  • Take the stairs instead of the elevator
  • Take a skateboard, bike or walk instead of getting a drive
  • Dance to your favourite music
  • Go to the playground or go for a walk
  • Teachers: Build active opportunities into daily classroom routines and encourage students to join a school sports team or simply to move around the classroom. It’s amazing how much fun walking around the school inside can be as a group!

Canadian physical activity guidelines for adults 18-64 years

Remember: Make sure you and your loved one stay hydrated, even during physical activities. Carrying a water bottle during any physical activity is recommended.

Heading home after a long day, most of us would just like to rest, relax and rid ourselves of stress. The last thing on the mind may be getting some exercise. But did you know that eating a ton of fatty or sugary foods and not getting enough physical activity puts stress on your liver? To continue reading click here.

Click here to access the Canadian 24-Hour Movement Guidelines for Children, Youth, Adults and Older Adults.

Sleep and Your Overall Health

If you were to weigh how important sleep is to your liver health, how far high up or down would it fall on the list? Sleep affects so many parts of life like our mental health, and it should be valued just as much as eating right and getting enough physical activity throughout the day. Many Canadians do not get enough sleep, and the impact can be seen on their liver health.

Sleep and your liver health

Insufficient sleep has been linked to a number of poor physical and mental health concerns, including an increased risk for developing a fatty liver. Lack of sleep can contribute to changes in your overall metabolism (like insulin resistance) that may affect the way your liver converts nutrients from the foods you eat, making it harder to maintain a healthy body weight. It can also make you feel more tired and sleepy during the day which also affects your overall physical activity level.

Health Canada recommends that getting at least 7-9 hours of sleep per night for adults is essential to maintain your health. Children need even more sleep time. Current guidelines recommend 9–11 hours of sleep per night for children ages 5–13 years old, and. 8–10 hours of sleep per night for children 14–17 years old.

Sleeping the recommended hours isn’t the only recipe for obtaining a healthy ‘sleep routine.’ It is also important to maintain a good pattern of sleep without interruptions that may prevent you from getting a good rest.

  • Be consistent. Go to bed at the same time each night and get up at the same time each morning, including on the weekends
  • Make sure your bedroom is quiet, dark, relaxing, and at a comfortable temperature
  • Limit accessing, watching or playing on electronic devices, such as TVs, computers/tablets, and smartphones, prior to sleep time.
  • Avoid large meals, caffeine, and alcohol before bedtime
  • Get some exercise. Being physically active during the day can help you fall asleep more easily at night.

Sleep Apnea

Lack of sleep can be due to a condition called sleep apnea. If you snore loudly and feel tired even after a full night’s sleep, you might have sleep apnea. One of the most common types of sleep apnea is obstructive sleep apnea, caused by your throat muscles relaxing and affecting the way air enters your lungs.

Common signs and symptoms of sleep apnea include snoring while sleeping, waking up gasping for air several times a night, morning headache, irritability and feeling sleepy during the day.  If you think you may have any of these symptoms, speak to your doctor or health care provider.

NAFLD and NASH Resource Library

Support

National Help Line:
This support resource gives you and your loved one somewhere to turn for answers after diagnosis, helps you understand your disease, and provides you with the resources you need.  You can call 1 (800) 563-5483 Monday to Friday from 9 AM to 5 PM EST.

The Peer Support Network:
This is a national network of people living with liver disease that have offered to share their experiences with others. It was developed by the Canadian Liver Foundation as a means to link Canadians like you who have a family member who has liver disease, who care for someone who suffers from liver disease, or who have been diagnosed with a liver disease, to talk about your concerns with a peer in a similar situation.

If you would like to be connected with a peer supporter in your area, or would like to join the peer support network, please call 1 (800) 563-5483 Monday to Friday from 9 AM to 5 PM EST or email us.

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